Polymeric or enzymatic degradation thus increasing the chances

 

Polymeric nanoparticles
(NPs) are colloidal carriers into which drugs are loaded in either solid state
or solution, adsorbed non-covalently or chemically linked to the surface Polymeric
nanoparticles (NPs) are colloidal carriers into which drugs are loaded in
either solid state or solution, adsorbed non-covalently or chemically linked to
the surface.1  In recent times,
PNPs are extensively employed as biomaterials because of their favourable
characteristics in terms of simple elaboration and design, good
biocompatibility, a broad structures variety and noticeable bio-imitative
characteristics. Expressly in smart drug delivery discipline, PNPs had a marked
role as they are able to bring therapeutics right into the purposed position in
human body, with excellent efficiency2. Polymeric NPs have been used
as a preferred nanoscale drug delivery vehicle especially for their high
encapsulation efficiency, excellent endocytosis efficiency, passive
tumor-targeting,  and delivery of a wide
range of therapeutic agents3.   These Np possess some advantages with respect
to single molecules of drugs or prodrugs, such as their high drug-loading
capacity. It is, therefore, possible to deliver a great number of drug
molecules into cells for each Np. In addition, Np provide protection to the
embedded drugs against chemical or enzymatic degradation thus increasing the
chances of the active molecule reaching the target site. Furthermore, it is
possible to modify the Np surface properties in order to facilitate drug
delivery, for example, escape from the RES system4.  Several polymers have been used to
produce NPs for CNS delivery using different preparation techniques depending
on polymer and drug features. Interestingly, aiming to increase their
circulation lifetime and improve drug delivery across BBB, NPs surface
properties can be modified by either adsorption or chemical grafting of
polyethylene glycol (PEG), poloxamers or other molecules, that increase their circulation
lifetime and improve drug delivery across the BBB.5 As
a result of the diversity of polymers, polymeric nanoparticles can be designed
to achieve desired properties such as controlled and/or sustained drug release
profile, as well as allowing drug release at the targeted site over a period of
time6

For this reason, a
variety of polymers have been investigated to form nanoparticles for brain drug
delivery.

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